ea0073aep5 | Adrenal and Cardiovascular Endocrinology | ECE2021
Moustogiannis Athanasios
, Karapanagioti Angeliki
, Nasiri-Ansari Narjes
, Zografos Giorgos
, Aggeli Chrysanthi
, Kyriakopoulos Georgios
, Choreftaki Theodosia
, Philippou Anastassios
, Kaltsas Gregory
, Kassi Evanthia
, Angelousi Anna
BackgroundRecent data have shown the anti-apoptotic effect of Chchd2 mitochondrial protein through the Bcl-2/Bax pathway in various cancers. Bax is regulated primarily by proteins-members of Bcl-2 family and mainly the Bcl-2 protein, which has been found to prevent Bax from accumulating in mitochondria. In response to apoptotic stimuli, Chchd2 decreases and loses its mitochondria localization accompanying by decreased Bcl-2/Bax interaction and increased ...